Grapiprant tablets AKA Galliprant for dogs is a pain-relieving medication. This drug is an industry first! It is ideal for the treatment of joint pain and discomfort associated with osteoarthritis. If your canine companion is starting to show signs of osteoarthritis pain, read on to find out about what you can do to put the spring back in their step!
Galliprant for Dogs: What is it and How Does it Work?
Ok, time to get technical… Galliprant is a prostaglandin E₂ (PGE₂) EP4 receptor antagonist; a non-cyclooxygenase (COX)-inhibiting, non-steroidal anti-inflammatory drug (NSAID). That is more than a mouthful, so let’s break it down:
Prostaglandin E₂ EP4 Receptor Antagonist
Prostaglandins are hormone-like lipids. They are produced at a site of injury or infection in the body. They are involved in the body’s response to this by controlling processes such as inflammation, blood flow, and the formation of blood clots.
Prostaglandin E₂ (PGE₂) is involved in controlling inflammatory pain, vasodilation (dilation/expansion of blood vessels), and increasing the permeability of the blood vessels amongst other things. PGE₂ applies its effects via four receptors; EP1, EP2, EP3, and EP4.
The EP4 receptor plays an important role in mediating pain and inflammation. A receptor antagonist, either by binding to the receptor or changing the shape of the receptor, prevents the usual hormone or molecule from binding. This puts a stop to the cascade of effects that would occur should the substrate (e.g PGE₂) bind with its receptor (e.g. EP4).
Non-Steroidal Anti-Inflammatory Drug
A non-steroidal anti-inflammatory drug (NSAID), e.g. Carprofen Rimadyl, Meloxicam, is as the name says. It is a drug that acts against inflammation, and it is not a steroid. Examples of steroidal drugs are cortisone, prednisone, etc.
Although these drugs have wonderful uses, they do have some unpleasant side-effects with extended use. This is not as much the case with non-steroidal drugs.
Cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) are enzymes integral in the formation of prostaglandins. Traditionally, NSAIDs block both COX-1 and COX-2 (e.g. aspirin). While blocking COX-2 is great – reduction in pain and inflammation, blocking COX-1 is not as good because it is important for the normal functioning of the kidneys and gastrointestinal tract (GIT).
Grapiprant specifically blocks the EP4 receptor without affecting the COX enzymes, thereby negating the side effects caused by inhibition of these enzymes.
Galliprant vs Gapiprant: What’s the Difference?
Grapiprant is the scientific name of this compound, while Galliprant is the name of the drug on the market. Galliprant for dogs is a registered trademark. It is indicated for the pain treatment of osteoarthritis.
Nature Knows Best: CBD Oil is a Natural Pain Reliever for Dogs!
The folks from Honest Paws have a line of products containing CBD (cannabidiol). CBD is a natural substance extracted from hemp plants.
It has many remedial properties (e.g. decreasing pain, reducing inflammation, fighting cancer, lowering heart rate and blood pressure) without being psychoactive or intoxicating. CBD is something that you can give your dog long term, without worrying about any harmful side-effects.
How Honest Paws CBD Oil, Soft Chews and Dog Treats Aid in Dog Pain Relief
Most CBD oils are made from hemp oil. They, therefore, contain only very small traces of THC, if any. CBD oil is fast acting to relieve arthritis pain, inflammation, and joint and mobility issues. Honest Paws CBD oil comes in a handy dropper bottle so that you can easily just add a droplet on your dog’s tongue or into their food.
Honest Paws Joint Support CBD Soft Chews are made from a veterinarian-grade CBD oil. To help improve joint health and mobility, they also contain active ingredients like chondroitin, glucosamine, and boswelia.
The tasty Turmeric Flavored Dog Treats from Honest Paws are designed to improve your dog’s health from within. These yummy treats contain the 100 % pure, full spectrum CBD oil to help ease joint pain and inflammation, as well as post-operative pain.
Why Pain Relief for Dogs with Osteoarthritis is Important!
Canine osteoarthritis (OA) is characterized by the breaking down of the cartilage (protective, cushioning tissue) between bones. This causes the bones to rub against each other. Which, in turn, can cause permanent joint damage, pain, inflammation, and lameness.
At this time osteoarthritis in dogs is incurable, but treating the pain is an option that can keep your doggo living life to the fullest. With the pain associated with OA, your dog is likely to become less active. This could lead to weight gain, which will, in turn, place even more stress on your dog’s joints, exacerbating the problem.
Limiting the pain by administering a drug like Galliprant for dogs can make your dog more comfortable and keep them active. Thus, preventing the vicious cycle!
The Benefits of Painkillers for Dogs
The importance of pain relief cannot be stressed enough. Dogs, especially large and giant breeds, regularly suffer from arthritis pain and reduced mobility, especially as they grow older.
If the issue becomes extreme, their quality of life can be affected. Dogs are so stoic. If you have just noticed the slightest little hint at pain in your dog, it is possibly a whole lot more painful than your pup is letting on. Giving your doggo the right kind of remedy to help ease that agony will go a long way in making life more comfortable for your fluffy friend.
Just beware! Do not reach for any old pain control medication that you might have in your medicine cabinet. Always check with your veterinarian first. Different pain meds help with different kinds of pain. While some human medicines might be ok for giving to your dogs, others might cause serious harm.
Safety: Is Galliprant Safe for Dogs?
Several studies have proven the efficacy of Grapiprant in the reduction of pain and inflammation in dogs with OA. If you believe your furry friend to be suffering from OA pain, Galliprant for dogs might be a perfect solution.
However, always check with your veterinarian first. When chatting to your vet about possible solutions, be sure to remember to let them know:
- Whether your dog has any history of heart disease.
- If your dog is on any other chronic pain medication.
- If your dog has experienced side effects to other NSAIDs.
- Whether your dog is a breeding dog, or is pregnant or lactating.
Galliprant 60mg, 20mg, or 100mg: What is the Safe Dosage for Dogs?
You should administer Galliprant for dogs at 0.9 mg/lb (2 mg/kg) once a day. E.g If your dog weighs 55 pounds, you will give 50 mg per day. It is advisable to use the lowest effective dosage for the shortest duration of time. Do not give the Galliprant with a meal as it is less efficiently absorbed.
The safety of Galliprant in dogs weighing less than 8 pounds or puppies younger than 9 months has not been evaluated. This drug has not been tested on pregnant or lactating dogs either. Galliprant is not safe for use in cats.
Potential Side Effects to Look Out For!
The side effects of NSAIDs typically occur in the digestive tract, kidney, and liver. Adverse reactions to Galliprant for dogs could include vomiting, diarrhea, a reduced appetite, lethargy, watery or bloody stools, and a reduction in blood albumin and total protein.
Other negative effects that have been reported are stomach and intestinal ulcers, perforations (holes) in the lining of the stomach and intestines, kidney failure, and liver failure.
Monitor your dog closely if you are giving it to them in the long term!
Signs and Symptoms of an Overdose or Allergic Reaction to Pain Pills for Dogs
If you suspect an overdose, the first port of call is to contact your veterinarian or a veterinarian emergency room.
In dogs, an allergic reaction most often manifests through the skin in the form of itchiness, swollen face, red skin, and/or hives. An allergic reaction can also present as anaphylaxis. Anaphylaxis causes pale gums, vomiting/diarrhea, difficulty in breathing, and even collapse.
If you suspect any reaction that might be due to the drugs, discontinue use immediately and inform your veterinarian.
Is There a Galliprant Rebate?
Yippee! Yes, there is a rebate for Galliprant! Galliprant for dogs is a prescription medicine. You should only purchase Galliprant from a veterinarian after having discussed your doggo’s symptoms and health issues with them.
If you pay with your credit card and keep your invoice, you can apply for a rebate.
Try Elancorebates.com and Hustle for That Bargain!
Do you want a rebate on that Galliprant that you just bought to help ease your pooch’s joint pain? Log on to www.elancorebates.com to fill in your promo code and date of purchase. Once you have completed the submission form, you could receive a rebate of up to $ 90. It’s as easy as that!